Serendipitous Synthesis of Pyridoquinazolinones <i>via</i> an Oxidative C–C Bond Cleavage
Matthias Brendel, Priyanka R. Sakhare, Gaurav Dahiya, Parthasarathi Subramanian, Krishna P. Kaliappan
Abstract
A direct one-pot copper-catalyzed oxidative C–C bond cleavage route to the synthesis of pyridoquinazolinones is described. This one-pot strategy involves a copper-catalyzed C–N coupling followed by concomitant C(sp3)–H oxidation and amidation via oxidative C–C bond cleavage under an O2 atmosphere to deliver the target molecules in high yields.
Topics & Concepts
ChemistryBond cleavageOxidative phosphorylationOxidative cleavageCleavage (geology)StereochemistryCombinatorial chemistryOrganic chemistryCatalysisBiochemistryFracture (geology)Geotechnical engineeringEngineeringQuinazolinone synthesis and applicationsCatalytic C–H Functionalization MethodsAdvanced Synthetic Organic Chemistry