Organ-specific cholesterol metabolic aberration fuels liver metastasis of colorectal cancer
Kaili Zhang, Wenwei Zhu, Shenghao Wang, Chao Gao, Jun-Jie Pan, Zunguo Du, Lu Lu, Hu‐Liang Jia, Qiongzhu Dong, Jinhong Chen, Ming Lü, Lun–Xiu Qin
Abstract
Our findings support the notion that CRC liver metastases show a specific cholesterol metabolic aberration. Targeting this cholesterol biosynthesis pathway could be a promising treatment for CRC liver metastasis.
Topics & Concepts
Colorectal cancerMetastasisCholesterolCancer researchMedicineCancerInternal medicineOncologyChemistryCancer, Lipids, and MetabolismLiver Disease Diagnosis and TreatmentDrug Transport and Resistance Mechanisms