Two-Component Signal Transduction Systems in the Human Pathogen Streptococcus agalactiae
Lamar S. Thomas, Laura C. Cook
Abstract
Streptococcus agalactiae (group B Streptococcus [GBS]) is an important cause of invasive infection in newborns, maternal women, and older individuals with underlying chronic illnesses. GBS has many mechanisms to adapt and survive in its host, and these mechanisms are often controlled via two-component signal transduction systems. In GBS, more than 20 distinct two-component systems (TCSs) have been classified to date, consisting of canonical TCSs as well as orphan and atypical sensors and regulators.
Topics & Concepts
Streptococcus agalactiaeBiologyMicrobiologyPathogenSignal transductionHuman pathogenStreptococcusStreptococcaceaeBacteriaCell biologyGeneticsAntibioticsNeonatal and Maternal InfectionsStreptococcal Infections and TreatmentsAntimicrobial Resistance in Staphylococcus