Characterization of Ferric Chloride-Induced Arterial Thrombosis Model of Mice and the Role of Red Blood Cells in Thrombosis Acceleration
Yeseul Shim, Il Kwon, Youngseon Park, Heow Won Lee, Jayoung Kim, Young Dae Kim, Hyo Suk Nam, Sungha Park, Ji Hoe Heo
Abstract
PURPOSE: )-induced thrombosis model is widely used for thrombosis research. However, it lacks standardization with uncertainty in the exact mechanism of thrombosis. This study aimed to characterize thrombus formation in a mouse model. MATERIALS AND METHODS: -induced thrombosis model. We also investigated thrombus histopathology using immunohistochemistry and electron microscopy. RESULTS: treatment area. Transmission electron microscopy showed that RBCs attached to and were surrounded by aggregates of degranulated platelets, suggesting their potential role in platelet activation. CONCLUSION: -induced thrombosis.
Topics & Concepts
ThrombusPlateletThrombosisFibrinFerricChemistryPlatelet activationPathologyMedicineBiophysicsInternal medicineImmunologyBiologyInorganic chemistryPlatelet Disorders and TreatmentsBlood properties and coagulationBlood Coagulation and Thrombosis Mechanisms