Harnessing Polyhydroxyalkanoates and Pressurized Gyration for Hard and Soft Tissue Engineering
Pooja Basnett, Rupy Kaur Matharu, Caroline S. Taylor, Upulitha Eranka Illangakoon, Jonathan I. Dawson, Janos M. Kanczler, Mehrie Behbehani, Eleanor J. Humphrey, Qasim A. Majid, Barbara Lukasiewicz, Rinat Nigmatullin, Phoebe Heseltine, Richard O. C. Oreffo, John W. Haycock, Cesare M. Terracciano, Siân E. Harding, Mohan Edirisinghe, Ipsita Roy
Abstract
models. Human induced pluripotent stem cell derived cardiomyocytes exhibited a mature cardiomyocyte phenotype with optimal calcium handling. This study confirms that engineered polyhydroxyalkanoate-based gyrospun fibers provide an exciting and unique toolbox for the development of scalable scaffolds for both hard and soft tissue regeneration.
Topics & Concepts
PolyhydroxyalkanoatesMaterials scienceRegeneration (biology)Tissue engineeringBiomedical engineeringScaffoldBiomaterialTransplantationEx vivoNanotechnologyCell biologyIn vivoBiologyMedicineBiotechnologySurgeryBacteriaGeneticsElectrospun Nanofibers in Biomedical ApplicationsTissue Engineering and Regenerative MedicineBone Tissue Engineering Materials