ATP-binding cassette transporters at the zebrafish blood-brain barrier and the potential utility of the zebrafish as an in vivo model
Jordan M. Hotz, Joanna R. Thomas, Emily N. Katz, Robert W. Robey, Sachi Horibata, Michael M. Gottesman
Abstract
) have become a model of interest for studies of the BBB due to the similarities between the zebrafish and mammalian BBB systems. In this review, we discuss what is known about ABC transporters in zebrafish and what information is still needed before the zebrafish can be recommended as a model to elucidate the role of ABC transporters at the BBB.
Topics & Concepts
ZebrafishATP-binding cassette transporterBlood–brain barrierAbcg2Cell biologyTransporterBiologyDanioEffluxDrug delivery to the brainIn vivoP-glycoproteinParacellular transportTight junctionGeneBiochemistryNeuroscienceGeneticsCentral nervous systemAntibioticsMembraneMultiple drug resistancePermeability (electromagnetism)Drug Transport and Resistance MechanismsBarrier Structure and Function StudiesNeonatal and fetal brain pathology