STAT3 gain-of-function mutations connect leukemia with autoimmune disease by pathological NKG2Dhi CD8+ T cell dysregulation and accumulation
Etienne Masle‐Farquhar, Katherine Jackson, Timothy J. Peters, Ghamdan Al‐Eryani, Mandeep Singh, Kathryn Payne, Geetha Rao, Danielle T. Avery, Gabrielle Apps, Jennifer Kingham, Christopher J. Jara, Ksenia Skvortsova, Alexander Swarbrick, S. Cindy, Daniel Suan, Gülbû Uzel, Ignatius Chua, Jennifer W. Leiding, Kaarina Heiskanen, Kahn Preece, Leena Kainulainen, Michael O’Sullivan, Megan A. Cooper, Mikko Seppänen, Satu Mustjoki, Shannon Brothers, Tiphanie P. Vogel, Robert Brink, Stuart G. Tangye, Joanne H. Reed, Christopher C. Goodnow
Abstract
T cell oligoclonal accumulation and that these rogue cells contribute to autoimmune pathology, supporting the hypothesis that somatic mutations in leukemia/lymphoma driver genes contribute to autoimmune disease.
Topics & Concepts
BiologyPerforinGranzymeCD8AutoimmunityImmunologyGranzyme BCytotoxic T cellT cellCancer researchImmune systemGeneticsIn vitroImmune Cell Function and InteractionT-cell and B-cell ImmunologyCAR-T cell therapy research