Adrenaline improves regional cerebral blood flow, cerebral oxygenation and cerebral metabolism during CPR in a porcine cardiac arrest model using low-flow extracorporeal support
Gabriel Putzer, Judith Martini, Patrick Spraider, Julia Abram, Rouven Hornung, Christine R. Schmidt, Marlies Bauer, Daniel Pinggera, Christoph Krapf, Tobias Hell, Bernhard Glodny, Raimund Helbok, Peter Mair
Abstract
BACKGROUND: The effects of adrenaline on cerebral blood vessels during cardiopulmonary resuscitation (CPR) are not well understood. We developed an extracorporeal CPR model that maintains constant low systemic blood flow while allowing adrenaline-associated effects on cerebral vasculature to be assessed at different mean arterial pressure (MAP) levels independently of the effects on systemic blood flow. METHODS: ) and extracellular cerebral metabolites assessed by cerebral microdialysis. RESULTS: to 15 ± 11% and 130 ± 82% (both p < 0.001) of baseline in the MAP 40 mmHg and MAP 60 mmHg groups, respectively. Importantly, MAP of 60 mmHg was associated with metabolic improvement. CONCLUSION: This study shows that adrenaline administration during constant low systemic blood flow increases CePP, regional CBF, cerebral oxygenation and cerebral metabolism.