A conserved motif in human BTG1 and BTG2 proteins mediates interaction with the poly(A) binding protein PABPC1 to stimulate mRNA deadenylation
Hamza Amine, Nina Ripin, Sahil Sharma, Georg Stoecklin, Frédéric H.‐T. Allain, Bertrand Séraphin, Fabienne Mauxion
Abstract
. Overall, our results identify the molecular interface allowing BTG1 and BTG2 to activate deadenylation, a process recently shown to be necessary for maintaining T-cell quiescence.
Topics & Concepts
BiologyPolyadenylationProtein–protein interactionPlasma protein bindingDNA-binding proteinCell biologyGeneticsConserved sequenceRNA-binding proteinHEK 293 cellsTranscription factorMessenger RNAPeptide sequenceGeneCancer-related gene regulationEpigenetics and DNA Methylation