Association of Adherent-invasive <i>Escherichia coli</i> with severe Gut Mucosal dysbiosis in Hong Kong Chinese population with Crohn’s disease
Zhilu Xu, Xiangqian Dong, Keli Yang, Caroline Chevarin, Jingwan Zhang, Yu Lin, Tao Zuo, Lok Cheung Chu, Yang Sun, Fengrui Zhang, Francis K.L. Chan, Joseph J.�Y. Sung, Jun Yu, Anthony Buisson, Nicolas Barnich, Jean–Frédéric Colombel, Sunny H. Wong, Yinglei Miao, Siew C. Ng
Abstract
. A random forest model predicted the presence of AIEC with area under the curve of 0.89. AIEC exacerbated dysbiosis in dextran sodium sulfate (DSS)-induced colitis mice and led to resistance to restoration of normal gut microbiota by fecal microbiota transplantation (FMT). Proportion of donor-derived bacteria in AIEC-colonized mice was significantly lower than that in uninfected mice. AIEC was prevalent and associated with severe mucosa microbiota dysbiosis in CD in Hong Kong Chinese population. The presence of AIEC impeded restoration of normal gut microbiota. AIEC may serve as a keystone bacterium in CD and impact the efficacy of FMT.