Practical and sustainable preparation of pyrrolo[2,3-<i>b</i>]indoles by Cu/Fe catalyzed intramolecular C(sp<sup>2</sup>)–H amination
Matteo Corrieri, Lucia De Crescentini, Fabio Mantellini, Giacomo Mari, Stefania Santeusanio, Gianfranco Favi
Abstract
The direct synthesis of pyrrolo[2,3- b ]indoles is developed using a Cu/Fe cocatalyzed intramolecular cycloamination of α-indolylhydrazones. This transformation proceeds cleanly and selectively at 50 °C in air, with water as the only reaction medium.
Topics & Concepts
Intramolecular forceAminationCatalysisChemistryMedicinal chemistryTransformation (genetics)Combinatorial chemistryStereochemistryOrganic chemistryGeneBiochemistryCatalytic C–H Functionalization MethodsCyclopropane Reaction MechanismsSynthesis and Catalytic Reactions