Activation of Nrf2 signaling by 4-octyl itaconate attenuates the cartilaginous endplate degeneration by inhibiting E3 ubiquitin ligase ZNF598
Bo Huang, Hao Wu, Lin Zheng, Xiaoan Wei, Z. Zheng, Hao Wu, Jie Chen, Zhaochen Shan, Jia Liu, Fengdong Zhao
Topics & Concepts
CatabolismInflammationDegeneration (medical)MacrophageOxidative stressIn vivoCell biologyUbiquitinReactive oxygen speciesLipopolysaccharideIn vitroDownregulation and upregulationBiologyChemistryMolecular biologyImmunologyPathologyBiochemistryMedicineGeneMetabolismGeneticsSpine and Intervertebral Disc PathologySpondyloarthritis Studies and TreatmentsOsteoarthritis Treatment and Mechanisms