Phosphomatics: interactive interrogation of substrate–kinase networks in global phosphoproteomics datasets
Michael G. Leeming, Sean O’Callaghan, Luana Licata, Marta Iannuccelli, Prisca Lo Surdo, Elisa Micarelli, Ching‐Seng Ang, Shuai Nie, Swati Varshney, S. Sadia Ameen, Heung‐Chin Cheng, Nicholas A. Williamson
Abstract
MOTIVATION: Mass spectrometry-based phosphoproteomics can routinely identify and quantify thousands of phosphorylated peptides from a single experiment. However interrogating possible upstream kinases and identifying key literature for phosphorylation sites is laborious and time-consuming. RESULTS: Here, we present Phosphomatics-a publicly available web resource for interrogating phosphoproteomics data. Phosphomatics allows researchers to upload phosphoproteomics data and interrogate possible relationships from a substrate-, kinase- or pathway-centric viewpoint. AVAILABILITY AND IMPLEMENTATION: Phosphomatics is freely available via the internet at: https://phosphomatics.com. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.