<i>In Vitro</i> and <i>In Vivo</i> Characterization of Tebipenem, an Oral Carbapenem
Nicole Cotroneo, Aileen Rubio, Ian A. Critchley, Chris M. Pillar, Michael J. Pucci
Abstract
The continued evolution of bacterial resistance to the β-lactam class of antibiotics has necessitated countermeasures to ensure continued effectiveness in the treatment of infections caused by bacterial pathogens. One relatively successful approach has been the development of new β-lactam analogs with advantages over prior compounds in this class. The carbapenems are an example of such β-lactam analogs possessing improved stability against β-lactamase enzymes and, therefore, a wider spectrum of activity.
Topics & Concepts
CarbapenemLactamAntibioticsIn vivoIn vitroMicrobiologyCephalosporinBeta-Lactamase InhibitorsPseudomonas aeruginosaBiologyChemistryMedicineBacteriaBiochemistryStereochemistryBiotechnologyGeneticsAntibiotics Pharmacokinetics and EfficacyAntibiotic Resistance in BacteriaAntibiotic Use and Resistance