Endosomal-associated RFFL facilitates mitochondrial clearance by enhancing PRKN/parkin recruitment to mitochondria
Rishith Ravindran, Anoop Kumar G. Velikkakath, Nikhil Dev Narendradev, Aneesh Chandrasekharan, T.R. Santhoshkumar, Srinivasa M. Srinivasula
Abstract
CCCP: carbonyl cyanide 3-chlorophenylhydrazone; DMSO: dimethyl sulfoxide; EGFP: enhanced green fluorescence protein; KO: knockout; PRKN: parkin RBR E3 ubiquitin protein ligase; RFFL: ring finger and FYVE like domain containing E3 ubiquitin protein ligase; UQCRC1: ubiquinol-cytochrome c reductase core protein 1; WT: wild-type.
Topics & Concepts
ParkinUbiquitin ligaseMitophagyEndosomeBiologyUbiquitinCell biologyMitochondrionUbiquitin-Protein LigasesDNA ligaseCullinSignal transducing adaptor proteinAutophagyBiochemistrySignal transductionParkinson's diseaseEnzymeGeneApoptosisPathologyMedicineDiseaseIntracellularAutophagy in Disease and TherapyParkinson's Disease Mechanisms and TreatmentsLysosomal Storage Disorders Research