Interplay between Meropenem and Human Serum Albumin on Expression of Carbapenem Resistance Genes and Natural Competence in Acinetobacter baumannii
Casin Le, Camila Pimentel, Marisel R. Tuttobene, Tomás Subils, Brent Nishimura, Germán M. Traglia, Federico Pérez, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Marcelo E. Tolmasky, María Soledad Ramirez
Abstract
gene, which was repressed in the presence of 3.5% HSA. In conclusion, HSA produces an enhancement of natural transformation and a modification in expression levels of competence genes and antibiotic resistance. Furthermore, when HSA is combined with carbapenems, which may increase the stress response, the expression of genes involved in natural competence is increased in A. baumannii. This process may favor the acquisition of foreign DNA and accelerate evolution.
Topics & Concepts
Acinetobacter baumanniiMeropenemMicrobiologyBiologyCarbapenemGeneBacteriaAntibiotic resistanceAntibioticsGeneticsPseudomonas aeruginosaAntibiotic Resistance in BacteriaAntibiotics Pharmacokinetics and EfficacyProtein Interaction Studies and Fluorescence Analysis