The roles of microRNA in redox metabolism and exercise-mediated adaptation
Ferenc Torma, Zoltán Gombos, Mátyás Jókai, I. Berkés, Masaki Takeda, Tatsuya Mimura, Zsolt Radák, Ferenc Győri
2020Journal of sport and health science/Journal of Sport and Health Science32 citationsDOIOpen Access PDF
Abstract
MicroRNAs (miRs) are small regulatory RNA transcripts capable of post-transcriptional silencing of mRNA messages by entering a cellular bimolecular apparatus called RNA-induced silencing complex. miRs are involved in the regulation of cellular processes producing, eliminating or repairing the damage caused by reactive oxygen species, and they are active players in redox homeostasis. Increased mitochondrial biogenesis, function and hypertrophy of skeletal muscle are important adaptive responses to regular exercise. In the present review, we highlight some of the redox-sensitive regulatory roles of miRs.
Topics & Concepts
microRNAGene silencingCell biologyFunction (biology)BiogenesisBiologySmall RNAMitochondrial biogenesisRedoxAdaptation (eye)ChemistryGeneBiochemistryNeuroscienceOrganic chemistryMicroRNA in disease regulationCircular RNAs in diseasesAdipose Tissue and Metabolism