The mitochondrial protein YME1 Like 1 is important for non-small cell lung cancer cell growth
Yingchen Xia, Chunyan He, Zhiwei Hu, Zhichao Wu, Hui Yin, Yuan-Yuan Liu, Chuanyong Mu, Jianhua Zha
Abstract
, subcutaneous NSCLC xenograft growth was remarkably slowed following intratumoral YME1L shRNA AAV injection in nude mice. YME1L knockdown, Akt-mTOR inactivation and ATP reduction were detected in YME1L-silenced NSCLC xenografts. Taken together, overexpressed YME1L in NSCLC exerts pro-tumorigenic function.
Topics & Concepts
Small hairpin RNACell growthCancer researchProtein kinase BPI3K/AKT/mTOR pathwayGene knockdownBiologyDownregulation and upregulationApoptosisTransfectionMitochondrionCell biologyChemistryMolecular biologyCell culturePhosphorylationSignal transductionBiochemistryGeneticsGeneRNA modifications and cancerRNA Research and SplicingGenomics and Chromatin Dynamics