Staphylococcus aureus Fibronectin Binding Protein A Mediates Biofilm Development and Infection
Casey M. Gries, Trevor Biddle, Jeffrey L. Bose, Tammy Kielian, David Lo
Abstract
Implanted medical device-associated infections pose significant health risks, as they are often the result of bacterial biofilm formation. Staphylococcus aureus is a leading cause of biofilm-associated infections which persist due to mechanisms of device surface adhesion, biofilm accumulation, and reprogramming of host innate immune responses. We found that the S. aureus fibronectin binding protein A (FnBPA) is required for normal biofilm development in mammalian serum and that the SaeRS two-component system is required for functional FnBPA activity in serum.
Topics & Concepts
Staphylococcus aureusBiofilmBiologyMicrobiologyFibronectinStaphylococcal infectionsBacterial proteinBacteriaBiochemistryGeneticsExtracellular matrixBacterial biofilms and quorum sensingAntimicrobial Resistance in StaphylococcusAntimicrobial Peptides and Activities