<p>An Iron Metabolism-Related <em>SLC22A17</em> for the Prognostic Value of Gastric Cancer</p>
Jianming Wei, Xibo Gao, Yulan Qin, Tong Liu, Yani Kang
Abstract
Purpose: Gastric cancer (GC) is a type of malignant cancer with a poor prognosis. The iron’s metabolism plays an important role in the process of GC. The aim of this study was to evaluate the effectiveness of SLC22A17 , associated with iron metabolism, in predicting the prognosis of GC patients. Materials and Methods: We analyzed genes related to iron metabolism of gastric cancer mRNA-seq data from TCGA database. We identified an iron metabolism-related SLC22A17 as an independent prognostic factor using univariate and multivariate Cox regression analysis. Results: Further research showed that SLC22A17 was related with many pathways involved in the process of gastric cancer, and the expression was associated with diverse cancer-infiltrating immune cells. The expression of SLC22A17 was associated with T (Topography). Conclusion: We validated that SLC22A17 associated with iron metabolism could serve as a prognostic biomarker for GC patients. Keywords: gastric cancer, iron metabolism, SLC22A17 , prognostic marker