Silencing PRSS1 suppresses the growth and proliferation of gastric carcinoma cells via the ERK pathway
Dongmei Ye, Yuxuan Li, Heliang Zhang, Zhiwei Zhou, Yujie Tang, Peng Wu, Qiang Zhao, Zhiwei Zhang
Abstract
miR-146a-5p targets PRSS1 and suppresses the growth and proliferation of MGC803 cells. Silencing PRSS1 expression inhibits the ERK signaling pathway by reducing PAR-2 activation, resulting in suppressed growth and proliferation of MGC803 GC cells.
Topics & Concepts
Gene silencingMAPK/ERK pathwayCancer researchCell growthSignal transductionMolecular biologyBiologyCell biologyGeneBiochemistryCancer, Lipids, and MetabolismCancer-related gene regulationMicroRNA in disease regulation