Vagal innervation limits brain injury by inhibiting gut-selective integrin-mediated intestinal immunocyte migration in intracerebral hemorrhage
Peiji Fu, Yan Zong, Yinming Dai, Lixia Zhu, Shuai Chen, Yousef Rastegar‐Kashkooli, Junmin Wang, Jiewen Zhang, Jian Wang, Chao Jiang
Abstract
: The identification of vagus nerve-mediated modulation of α4β7 and αEβ7 integrin expression in the trafficking of immune cells within the intestinal tract holds significant implications. This discovery presents new opportunities for developing therapeutic interventions for ICH and stimulates further investigation in this area.
Topics & Concepts
Intracerebral hemorrhageIntegrinMedicinePathologyNeuroscienceImmunologyInternal medicineBiologyReceptorSubarachnoid hemorrhageIntracerebral and Subarachnoid Hemorrhage Research