Deletion of <i>Abi3</i> gene locus exacerbates neuropathological features of Alzheimer’s disease in a mouse model of Aβ amyloidosis
Hande Karahan, Daniel C. Smith, Byung-Wook Kim, Luke C. Dabin, Md. Mamun Al-Amin, H. R. Sagara Wijeratne, Taylor Pennington, Gonzalo Viana Di Prisco, Brianne McCord, Peter Bor‐Chian Lin, Yuxin Li, Junmin Peng, Adrian L. Oblak, Shaoyou Chu, Brady K. Atwood, Jungsu Kim
Abstract
knockdown in microglia impairs migration and phagocytosis. Together, our study provides the first in vivo functional evidence that loss of ABI3 function may increase the risk of developing AD by affecting Aβ accumulation and neuroinflammation.
Topics & Concepts
AmyloidosisLocus (genetics)GeneAlzheimer's diseaseDiseaseBiologyGeneticsAmyloid (mycology)NeuropathologyMedicinePathologyNeuroscienceAlzheimer's disease research and treatmentsNuclear Receptors and SignalingNeurogenesis and neuroplasticity mechanisms