Litcius/Paper detail

Thioester-mediated biocatalytic amide bond synthesis with in situ thiol recycling

Christian Schnepel, Laura Rodríguez Pérez, Yuqi Yu, Antonio Angelastro, Rachel S. Heath, Max Lubberink, Francesco Falcioni, Keith R. Mulholland, Martin A. Hayes, Nicholas J. Turner, Sabine L. Flitsch

2022Nature Catalysis50 citationsDOIOpen Access PDF

Topics & Concepts

ThioesterAdenylylationCoenzyme AChemistryAmideAmino acidLysineAcylationAcyltransferasesBiochemistryPeptide bondEnzymeReductaseStereochemistryBiosynthesisCatalysisChemical Synthesis and AnalysisPeptidase Inhibition and AnalysisClick Chemistry and Applications