Thioester-mediated biocatalytic amide bond synthesis with in situ thiol recycling
Christian Schnepel, Laura Rodríguez Pérez, Yuqi Yu, Antonio Angelastro, Rachel S. Heath, Max Lubberink, Francesco Falcioni, Keith R. Mulholland, Martin A. Hayes, Nicholas J. Turner, Sabine L. Flitsch
Topics & Concepts
ThioesterAdenylylationCoenzyme AChemistryAmideAmino acidLysineAcylationAcyltransferasesBiochemistryPeptide bondEnzymeReductaseStereochemistryBiosynthesisCatalysisChemical Synthesis and AnalysisPeptidase Inhibition and AnalysisClick Chemistry and Applications