Probing the cell delivery of synthetic diubiquitin chains
Shaswati Mandal, Ashraf Brik
Abstract
In this study, the live-cell delivery of structurally different synthetic diubiquitin chains was examined. We found that the combination of structural variations of the Ub chains (intrinsic factors); nature of CPP and CPP-protein linkage (extrinsic factors) influence their delivery.
Topics & Concepts
ChemistryNanotechnologyCombinatorial chemistryMaterials scienceUbiquitin and proteasome pathwaysGenetics and Neurodevelopmental DisordersGlycosylation and Glycoproteins Research