Chlorogenic acid releasing microspheres enhanced electrospun conduits to promote peripheral nerve regeneration
Jiaqi Fang, Xuehan Jin, Bo Xu, Liping Nan, Shuhao Liu, Jianguang Wang, Na Niu, Zhong Wu, Feng Chen, Junjian Liu
Abstract
PNI regeneration, compared with PCL conduits. The sciatic nerve functional index analysis, electrophysiological examination, and immunological analysis performed to evaluate the functional recovery of the injurious sciatic nerve of rats have indeed proved the favorable effects of CGM/PCL conduits. The result of this study not only aimed to explore CGA's contribution to nerve regeneration but also provided a new strategy for designing and preparing functional NGCs for PNI treatment.
Topics & Concepts
Regeneration (biology)Sciatic nervePeripheral nerve injuryNerve guidance conduitIn vivoChemistryBiomedical engineeringPharmacologyMedicineAnatomyCell biologyBiologyBiotechnologyNerve injury and regenerationElectrospun Nanofibers in Biomedical ApplicationsGraphene and Nanomaterials Applications