Harnessing the intrinsic photochemistry of isoxazoles for the development of chemoproteomic crosslinking methods
Marshall G. Lougee, Vinayak Vishnu Pagar, Hee Jong Kim, Samantha X. Pancoe, Wai‐Kit Chia, Robert H. Mach, Benjamin A. Garcia, E. James Petersson
Abstract
The intrinsic photochemistry of the isoxazole, a common heterocycle in medicinal chemistry, can be applied to offer an alternative to existing strategies using more perturbing, extrinsic photo-crosslinkers. The utility of isoxazole photo-crosslinking is demonstrated in a wide range of biologically relevant experiments, including common proteomics workflows.
Topics & Concepts
IsoxazoleChemistryCombinatorial chemistryNanotechnologyRange (aeronautics)PhotochemistryComputer scienceMaterials scienceOrganic chemistryComposite materialClick Chemistry and ApplicationsAdvanced Biosensing Techniques and ApplicationsChemical Synthesis and Analysis