RUNX1 promotes mitophagy and alleviates pulmonary inflammation during acute lung injury
Tang Xiao-ju, Lichun Zhong, Xin Tian, Ying Zou, Silu Hu, Jia Liu, Ping Li, Min Zhu, Fengming Luo, Huajing Wan
Abstract
Acute lung injury (ALI) is a significant contributor to the development of acute respiratory distress syndrome (ARDS), which is a severe clinical condition associated with high morbidity and mortality. 1 It is increasingly evident that preserving mitochondrial health in alveolar epithelial cells holds great therapeutic potential for ARDS. 2 Mitophagy, a cellular process aimed at maintaining mitochondrial health, plays a critical role in this regard. 3 Therefore, gaining a comprehensive understanding of the factors that regulate mitophagy in alveolar epithelial cells during ALI could greatly inform the development of future therapeutic approaches for ARDS.