A review of the research progress in T-lymphocyte immunity and cervical cancer
Lina Zhang, Zhilei Mao, Yiqing Lai, Ting Wan, Keliang Zhang, Beibei Zhou
Abstract
Cervical cancer develops as a result of T-cell immune evasion by human papillomavirus (HPV). T-cell immunity requires the participation of many factors, such as antigen-presenting cells (APCs), cytokines, co-stimulatory molecules, etc. HPV vaccines are promising treatments to prevent HPV infection and cervical cancer. This article mainly provides a summary of the number and function changes of T cells during HPV infection and cervical cancer development. Studies on t-cell immunotherapy, which is expected to become a new treatment for cervical cancer after surgery, radiotherapy, and chemotherapy, are also reviewed in this article.
Topics & Concepts
Cervical cancerImmunityMedicineImmunologyImmunotherapyImmune systemCancerRadiation therapyEvasion (ethics)VaccinationAntigenT cellCellular immunityHuman papillomavirusOncologyInternal medicineCervical Cancer and HPV ResearchCancer Immunotherapy and BiomarkersImmunotherapy and Immune Responses