A BODIPY-based fluorescent sensor for the detection of Pt2+ and Pt drugs
Fung‐Kit Tang, Jiaqian Zhu, Fred Ka‐Wai Kong, Maggie Ng, Qingyuan Bian, Vivian Wing‐Wah Yam, Anfernee Kai‐Wing Tse, Yu-Chung Tse, Ken Cham‐Fai Leung
Abstract
A BODIPY-based fluorescent sensor PS with an NO4S2 podand ligand was studied for the selective detection of Pt2+ over 21 cations as well as selected platinum drugs in aqueous medium. The platinum sensor PS shows 28-fold, 22-fold and 14-fold fluorescence turn-on enhancements to Pt2+, cisplatin and nedaplatin, and was thereby employed to detect platinum drugs in A-549 human lung cancer cells.
Topics & Concepts
FluorescencePlatinumBODIPYCisplatinNedaplatinChemistryAqueous solutionCombinatorial chemistryPlatinum nanoparticlesLigand (biochemistry)PhotochemistryBiochemistryOrganic chemistryReceptorChemotherapyBiologyPhysicsQuantum mechanicsCatalysisGeneticsAdvanced biosensing and bioanalysis techniquesMolecular Sensors and Ion DetectionMetal complexes synthesis and properties