CPK12 and Ca <sup>2+</sup> -mediated hypoxia signaling
Santosh Kumar Upadhyay
Abstract
Hypoxia triggers reactive oxygen species (ROS)-induced elevation in cytoplasmic calcium (Ca 2+ ) in the plant cells.Calcium-dependent protein kinase 12 (CPK12) acts as a sensor to recognize the Ca 2+ signature and is activated by autophosphorylation.Then, the CPK12 moves into the nucleus with the help of phosphatidic acid (PA) and phosphorylates ERF-VII family proteins that activate hypoxia signaling and response.The study provides a novel mechanism of hypoxia signaling in plants.Moreover, the mechanism of hypoxia-specific Ca 2+ signature generation remains elusive.
Topics & Concepts
BiologyAutophosphorylationCell biologyHypoxia (environmental)Phosphatidic acidSignal transductionCalciumPhosphorylationCalcium signalingReactive oxygen speciesBiochemistryProtein kinase AOxygenChemistryPhospholipidMembraneOrganic chemistryPlant responses to water stressPlant Stress Responses and TolerancePlant nutrient uptake and metabolism