Transfer hydrogenation of pyridinium and quinolinium species using ethanol as a hydrogen source to access saturated N-heterocycles
Suman Yadav, Dhananjay Chaudhary, Naveen Kumar Maurya, Dharmendra Kumar, Km Ishu, Malleswara Rao Kuram
Abstract
Catalytic transfer hydrogenation (TH) for the reduction of heterocycles is an emerging strategy for accessing biologically active saturated N-heterocycles. Herein, we report a TH protocol that utilizes ethanol as a renewable hydrogen source and an Ir catalyst for the reduction of quinolines and pyridines. The reaction is promoted by simple amides as ligands.
Topics & Concepts
ChemistryCatalysisTransfer hydrogenationEthanolPyridiniumCombinatorial chemistryHydrogenOrganic chemistryRutheniumAsymmetric Hydrogenation and CatalysisChemical Synthesis and AnalysisNanomaterials for catalytic reactions