Stromal cell protein kinase C-β inhibition enhances chemosensitivity in B cell malignancies and overcomes drug resistance
Eugene Park, Jingyu Chen, A. P. Moore, Maurizio Mangolini, Antonella Santoro, Joseph R. Boyd, Hilde Schjerven, Veronika Ecker, Maike Buchner, James C. Williamson, Paul J. Lehner, Luca Gasparoli, Owen Williams, Johannes Bloehdorn, Stephan Stilgenbauer, Michael Leitges, Alexander Egle, Marc Schmidt‐Supprian, Seth Frietze, Ingo Ringshausen
Abstract
) in tumor cells. Central to the stroma-mediated drug resistance is the PKC-β-dependent activation of transcription factor EB, regulating lysosome biogenesis and plasma membrane integrity. Stroma-directed therapies, enabled by direct inhibition of PKC-β, enhance the effectiveness of many antileukemic therapies.
Topics & Concepts
Stromal cellCancer researchDrug resistanceProtein kinase ACellChemosensitivity assayDrugKinaseChemistryMedicineBiologyPharmacologyCell biologyTumor cellsBiochemistryGeneticsChronic Lymphocytic Leukemia ResearchMultiple Myeloma Research and TreatmentsPI3K/AKT/mTOR signaling in cancer