The secondary pocket of cryptochrome 2 is important for the regulation of its stability and localization
Gizem Cagla Parlak, Bilge Bahar Camur, Şeref Gül, Onur Özcan, İbrahim Barış, İbrahim Halil Kavaklı
Abstract
double KO mouse embryonic fibroblast cell line. Collectively, our data suggest that the rim of the secondary pocket of CRY2 plays a significant role in its nuclear localization independently of PER2 and in the intact circadian rhythm at the cellular level.
Topics & Concepts
CryptochromeCell biologyBiologyChemistryGeneticsGeneCircadian clockCircadian rhythm and melatoninLight effects on plantsPhotoreceptor and optogenetics research