Biogenic selenium nanoparticles alleviate intestinal epithelial barrier injury by regulating mitochondria–lysosome crosstalk
Xina Dou, Lei Qiao, Xiaofan Song, Jiajing Chang, Shanyao Pi, Xinyi Zhang, Xiaonan Zeng, Lixu Zhu, Chunlan Xu
Abstract
concentration and activated the TBC1D15/Fis/Rab7-mediated signaling pathway, shortened the contact time between mitochondria and lysosomes, inhibited mitophagy, maintained mitochondrial and lysosomal homeostasis, and effectively attenuated intestinal epithelial barrier injury in IPEC-J2 cells transfected with TBC1D15 siRNA. These results indicated that the protective effect of SeNPs on intestinal epithelial barrier injury is closely associated with the TBC1D15/Rab7-mediated mitochondria-lysosome crosstalk signaling pathway.
Topics & Concepts
Cell biologyAutophagyMitophagyLysosomeMitochondrionCrosstalkIntestinal mucosaIntestinal epitheliumTransfectionBiologyChemistryApoptosisEpitheliumCell cultureBiochemistryMedicineInternal medicineGeneticsPhysicsEnzymeOpticsAutophagy in Disease and TherapySelenium in Biological SystemsTrace Elements in Health