Fabrication of polyethylene terephthalate (PET) nanoparticles with fluorescent tracers for studies in mammalian cells
Leah M. Johnson, Jeffrey B. Mecham, Sai Archana Krovi, Maria Moreno Caffaro, Shyam Aravamudhan, Alexander L. Kovach, Timothy R. Fennell, Ninell P. Mortensen
Abstract
Fluorescent nanoparticles (NPs) comprising polyethylene terephthalate (PET) with a hydrodynamic diameter of 158 ± 2 nm were synthesized in a bottom-up approach. Concentration-dependent uptake and cytotoxicity of PET NPs in macrophages are shown. The fabrication of well-characterized NPs, derived from high-commodity polymers, will support future studies to assess effects on biological systems.
Topics & Concepts
Polyethylene terephthalateFluorescenceFabricationMaterials scienceNanoparticleNanotechnologyPolyethyleneChemical engineeringComposite materialOpticsPathologyPhysicsAlternative medicineEngineeringMedicineMicroplastics and Plastic PollutionGraphene and Nanomaterials ApplicationsAdditive Manufacturing and 3D Printing Technologies