New insights into the natural history of bronchopulmonary dysplasia from proteomics and multiplexed immunohistochemistry
Andrew M. Dylag, Ravi Misra, Gautam Bandyopadhyay, Cory Poole, Heidie Huyck, M. Jehrio, Jeannie Haak, Gail Deutsch, Carly Dvorak, Heather Olson, Vanessa Paurus, Philip J. Katzman, Jongmin Jacob Woo, Jeffrey M. Purkerson, Joshua Adkins, Thomas J. Mariani, Gérémy Clair, Gloria Pryhuber
2023American Journal of Physiology-Lung Cellular and Molecular Physiology21 citationsDOIOpen Access PDF
Abstract
We provide new insights into the natural history of bronchopulmonary dysplasia in donor human lungs after the neonatal intensive care unit hospitalization. This study provides new insights into how the proteome and histopathology of BPD changes in early childhood, uncovering novel pathways for future study.
Topics & Concepts
Bronchopulmonary dysplasiaProteomicsWestern blotBiologyPathologyProteomeLungDownregulation and upregulationImmunohistochemistryAndrologyImmunologyMedicineBioinformaticsInternal medicineGeneticsGeneGestational agePregnancyNeonatal Respiratory Health ResearchCongenital Diaphragmatic Hernia StudiesInfant Nutrition and Health