Sustained AT1R stimulation induces upregulation of growth factors in human cardiac fibroblasts via Gαq/TGF-β/ERK signaling that influences myocyte hypertrophy
Ratchanee Duangrat, Warisara Parichatikanond, Noppawan Phumala Morales, Darawan Pinthong, Supachoke Mangmool
Topics & Concepts
Angiotensin IIDownregulation and upregulationCTGFInternal medicineEndocrinologyGrowth factorFibrosisCardiac fibrosisSignal transductionTransforming growth factorMuscle hypertrophyLosartanBiologyMedicineCell biologyReceptorGeneBiochemistryCardiac Fibrosis and RemodelingPulmonary Hypertension Research and TreatmentsConnective Tissue Growth Factor Research