Progress and gaps of extracellular vesicle-mediated intercellular cargo transfer in the central nervous system
Chun Wan, Michael H. B. Stowell, Jingshi Shen
Abstract
A fundamentally novel function proposed for extracellular vesicles (EVs) is to transfer bioactive molecules in intercellular signaling. In this minireview, we discuss recent progress on EV-mediated cargo transfer in the central nervous system (CNS) and major gaps in previous studies. We also suggest a set of experiments necessary for bridging the gaps and establishing the physiological roles of EV-mediated cargo transfer.
Topics & Concepts
ExtracellularIntracellularExtracellular vesiclesCentral nervous systemExtracellular vesicleBridging (networking)NeuroscienceCell biologyGap junctionFunction (biology)Nervous systemBiologyChemistryMicrovesiclesComputer scienceBiochemistrymicroRNAGeneComputer networkExtracellular vesicles in diseaseCell Adhesion Molecules ResearchPhagocytosis and Immune Regulation