Light-Mediated Difluoromethylthiolation of Aldehydes with a Hydrogen Atom Transfer Photocatalyst
Jianyang Dong, Fuyang Yue, Xiaochen Wang, Hongjian Song, Yuxiu Liu, Qingmin Wang
Abstract
H and a decatungstate photocatalyst under redox-neutral conditions has been developed. This reaction is highly efficient, scalable, and oxidant-free. The broad substrate scope and excellent functional group tolerance of the reaction make it suitable for generating libraries of difluoromethyl thioesters. We demonstrated the utility and sustainability of the method by synthesizing several structurally complex difluoromethyl thioesters.
Topics & Concepts
ChemistryPhotocatalysisSubstrate (aquarium)Scope (computer science)Hydrogen atomFunctional groupCombinatorial chemistryRedoxReaction conditionsPhotochemistryScalabilityCatalysisGroup (periodic table)Organic chemistryComputer scienceDatabaseProgramming languageGeologyPolymerOceanographyFluorine in Organic ChemistryInorganic Fluorides and Related CompoundsSulfur-Based Synthesis Techniques