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Pharmacologic modulation of RNA splicing enhances anti-tumor immunity

Sydney X. Lu, Emma De Neef, James D. Thomas, Erich Sabio, Benoı̂t Rousseau, Mathieu Gigoux, David A. Knorr, Benjamin D. Greenbaum, Yuval Elhanati, Simon J. Hogg, Andrew Chow, Arnab Ghosh, Abigail Xie, Dmitriy Zamarin, Daniel Cui, Caroline Erickson, Michael Singer, Hana Cho, Eric Wang, Bin Lü, Benjamin H. Durham, Harshal Shah, Diego Chowell, Austin M. Gabel, Yudao Shen, Jing Liu, Jian Jin, Matthew C. Rhodes, Richard E. Taylor, Henrik Molina, Jedd D. Wolchok, Taha Merghoub, Luis A. Díaz, Omar Abdel‐Wahab, Robert K. Bradley

2021Cell279 citationsDOIOpen Access PDF

Topics & Concepts

RNA splicingBiologyAlternative splicingImmune checkpointMinigeneCancer researchMHC class IRNACell biologyImmune systemImmunotherapyMajor histocompatibility complexImmunologyGeneticsMessenger RNAGenePeptidase Inhibition and AnalysisRNA modifications and cancerRNA and protein synthesis mechanisms
Pharmacologic modulation of RNA splicing enhances anti-tumor immunity | Litcius