A Candidate Gene Cluster for the Bioactive Natural Product Gyrophoric Acid in Lichen-Forming Fungi
Garima Singh, Anjuli Calchera, Dominik Merges, Henrique Valim, Jürgen Otte, Imke Schmitt, Francesco Dal Grande
Abstract
The implementation of natural products in the pharmaceutical industry relies on the possibility of modifying the natural product (NP) pathway to optimize yields and pharmacological effects. Characterization of genes and pathways underlying natural product biosynthesis is a major bottleneck for exploiting the medicinal properties of the natural products.
Topics & Concepts
Natural productBottleneckNatural (archaeology)Gene clusterComputational biologyProduct (mathematics)GeneBiologyChemistryBiochemistryComputer scienceMathematicsEmbedded systemPaleontologyGeometryLichen and fungal ecologyMicrobial Natural Products and BiosynthesisFungal Biology and Applications