<i>Fusobacterium nucleatum</i> Secretes Outer Membrane Vesicles and Promotes Intestinal Inflammation
Melinda A. Engevik, Heather A. Danhof, Wenly Ruan, Amy C. Engevik, Alexandra L. Chang‐Graham, Kristen A. Engevik, Zhongcheng Shi, Yanling Zhao, Colleen K. Brand, Evan Krystofiak, Susan Venable, Xinli Liu, Kendal D. Hirschi, Joseph M. Hyser, Jennifer K. Spinler, Robert A. Britton, James Versalovic
Abstract
Several studies have identified an increased abundance of Fusobacterium in the intestinal tracts of patients with colon cancer, liver cirrhosis, primary sclerosing cholangitis, gastroesophageal reflux disease, HIV infection, and alcoholism. However, the direct mechanism(s) of action of Fusobacterium on pathophysiological within the gastrointestinal tract is unclear.
Topics & Concepts
Fusobacterium nucleatumProinflammatory cytokineInflammationTumor necrosis factor alphaMicrobiologyTLR4CCL20ImmunologyBiologyChemokinePorphyromonas gingivalisBacteriaGeneticsChemokine receptorGut microbiota and healthClostridium difficile and Clostridium perfringens researchNosocomial Infections in ICU