Synthesis, COX-2 inhibition and metabolic stability studies of 6-(4-fluorophenyl)-pyrimidine-5-carbonitrile derivatives as anticancer and anti-inflammatory agents
Wasim Akhtar, Lalit Mohan Nainwal, Mohemmed Faraz Khan, Garima Verma, Gousia Chashoo, Afroz Bakht, Muzaffar Iqbal, Mymoona Akhtar, Mohammad Shaquiquzzaman, Mohammad Mumtaz Alam
Topics & Concepts
ChemistryPyrimidineThio-In vivoNucleophilic substitutionPotencyGrowth inhibitionStereochemistryUracilIn vitroPharmacologyMedicinal chemistryBiochemistryMedicineDNABiotechnologyBiologySynthesis and biological activitySynthesis and Characterization of Heterocyclic CompoundsSynthesis of heterocyclic compounds