<scp>Cobalt‐Catalyzed</scp> Enantioselective <scp>Ring‐Opening</scp> Reactions of Oxa‐ and Aza‐bicyclic Alkenes with Alkenylboronic Acids
Di Zhu, Yongmei Zhao, Qinglei Chong, Fanke Meng
Abstract
Comprehensive Summary Catalytic enantioselective ring‐opening of oxa‐ and aza‐bicyclic alkenes with readily available accessible alkenylboronic acids, promoted by a chiral phosphine–Co complex, is reported. Such a process represents the unprecedented Co‐catalyzed introduction of various alkenyl groups onto the oxa‐ and aza‐bicyclic alkenes, affording a wide range of multisubstituted functionalized cyclohexenes in up to 98% yield and 99.5 : 0.5 er.
Topics & Concepts
Bicyclic moleculeChemistryCatalysisYield (engineering)Ring (chemistry)PhosphineEnantioselective synthesisCobaltOrganic chemistryCombinatorial chemistryMedicinal chemistryMetallurgyMaterials scienceCatalytic C–H Functionalization MethodsCyclopropane Reaction MechanismsAsymmetric Hydrogenation and Catalysis