Nickel‐Catalyzed Reductive Amidation of Aryl Sulfonium Salts with Isocyanates for Amide Synthesis via C−S Bond Activation
Xue Chen, Mengke Xu, X. Zhang, Chengping Miao, Xue‐Qiang Chu, Weidong Rao, Hao Xu, Hao Xu, Xiaocong Zhou, Xiaocong Zhou, Zhi‐Liang Shen
Abstract
Abstract A nickel‐catalyzed reductive amidation of aryl sulfonium salts with isocyanates for amide synthesis via C−S bond cleavage was developed. The reactions proceeded smoothly at ambient temperature in the presence of nickel catalyst and manganese metal in DMF to give a variety of amides in moderate to good yields with wide functional group tolerance.
Topics & Concepts
ChemistrySulfoniumArylCatalysisAmideNickelPolymer chemistryOrganic chemistryCombinatorial chemistryMedicinal chemistrySalt (chemistry)AlkylChemical Synthesis and AnalysisSulfur-Based Synthesis TechniquesChemical Synthesis and Reactions