Hepatic metabolic regulation by nuclear factor E4BP4
Zifeng Zhao, Lei Yin, Feihua Wu, Xin Tong
Abstract
Discovered as a b-ZIP transcription repressor 30 years ago, E4 promoter-binding protein 4 (E4BP4) has been shown to play critical roles in immunity, circadian rhythms, and cancer progression. Recent research has highlighted E4BP4 as a novel regulator of metabolisms in various tissues. In this review, we focus on the function and mechanisms of hepatic E4BP4 in regulating lipid and glucose homeostasis, bile metabolism, as well as xenobiotic metabolism. Finally, E4BP4-specific targets will be discussed for the prevention and treatment of metabolic disorders.
Topics & Concepts
RegulatorTranscription factorRepressorMetabolic regulationChemistryCell biologyXenobioticTranscriptional regulationBiochemistryFunction (biology)Transcription (linguistics)Nuclear receptorBiologyDownregulation and upregulationMaster regulatorRegulation of gene expressionLipid metabolismMetabolismGene isoformNegative regulatorPI3K/AKT/mTOR signaling in cancerCholesterol and Lipid MetabolismCancer, Hypoxia, and Metabolism