Combined effects of mesenchymal stem cells carrying cytosine deaminase gene with 5-fluorocytosine and temozolomide in orthotopic glioma model.
Da‐Young Chang, Jin-Hwa Jung, Andrew Aujin Kim, Subash Marasini, Young Jun Lee, Sun Ha Paek, Sung‐Soo Kim, Haeyoung Suh‐Kim
Abstract
. Combined treatment with TMZ and 5-FU increased cell cycle arrest and DNA breakage. In an orthotopic xenograft mouse model, treatment with TMZ alone suppressed tumor growth; however, this effect was more intense with MSC/CD transplantation followed by the sequential treatment with 5-FC and TMZ. Therefore, we propose that sequential treatment with 5-FC and MSC/CD can be used in patients with GBM during the immediate postoperative period to sensitize tumors to subsequent adjuvant chemo- and radiotherapy.
Topics & Concepts
TemozolomideCytosine deaminaseCancer researchGliomaMesenchymal stem cellMedicineIn vivoTransplantationBiologyGenetic enhancementInternal medicinePathologyGeneBiotechnologyBiochemistryGlioma Diagnosis and TreatmentCancer Research and TreatmentsCancer, Hypoxia, and Metabolism