Advances in the understanding of the role and mechanism of action of PFKFB3‑mediated glycolysis in liver fibrosis (Review)
Qian Liu, Jiajia Li, Xin Li, Li Zhang, Shun Yao, Yongfeng Wang, Biguang Tuo, Hai Jin
Abstract
Liver fibrosis is a pathophysiologic manifestation of chronic liver disease and a precursor to cirrhosis and hepatocellular carcinoma.Glycolysis provides intermediate metabolites as well as energy support for cell proliferation and phenotypic transformation in liver fibers.6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) is a key activator of glycolysis and plays an important role in the process of glycolysis.The role of PFKFB3-mediated glycolysis in myocardial fibrosis, renal fibrosis and pulmonary fibrosis has been demonstrated, and the role of PFKFB3 in the activation of hepatic stellate cells by aerobic glycolysis has been proven by relevant experiments.The present study reviews the research progress on the role and mechanism of action of PFKFB3-mediated glycolysis in the progression of hepatic fibrosis to discuss the role of PFKFB3-mediated glycolysis in hepatic fibrosis and to provide new ideas for research on PFKFB3 as a target for the treatment of hepatic fibrosis. Contents1. Introduction 2. Methodology 3. General characteristics of PFKFB3 4. Relationship between PFKFB3 and glycolysis 5. Relationships between PFKFB3-mediated glycolysis and liver fibrosis 6. Prospects for PFKFB3-mediated glycolysis 7. conclusion