Enantioselective Reductive Coupling of Imines Templated by Chiral Diboron
Mingkang Zhou, Li Kaidi, Dongping Chen, Ronghua Xu, Guangqing Xu, Wenjun Tang
Abstract
We herein report a general, practical, and highly efficient method for asymmetric synthesis of a wide range of chiral vicinal diamines via reductive coupling of imines templated by chiral diboron. The protocol features high enantioselectivity and stereospecificity, mild reaction conditions, simple operating procedures, use of readily available starting materials, and a broad substrate scope. The method signifies the generality of diboron-enabled [3,3]-sigmatropic rearrangement.
Topics & Concepts
ChemistryEnantioselective synthesisStereospecificityVicinalCombinatorial chemistrySubstrate (aquarium)Computational chemistryOrganic chemistryCatalysisGeologyOceanographyAsymmetric Hydrogenation and CatalysisOrganoboron and organosilicon chemistryAdvanced Synthetic Organic Chemistry